In this video, surgeon Christian Bermudez, MD, examines extracorporeal membrane oxygenation (ECMO) from a practical perspective in the light of recent studies and relevant experiences at Penn Medicine. Topics include indications and contraindications for use, approaches to implementation, the advantages of ECMO by comparison to other percutaneous options, ways to optimize the likelihood of myocardial recovery, and the variables involved in bridging and exit strategies.