In this engaging video, Ivona Percec, MD, PhD, discusses established and evolving therapies for facial rejuvenation, including a review of the gold standard, fat grafting, and an examination of the evolving cosmetic stem cell therapies. A clinical researcher as well as practicing plastic surgeon, Dr. Percec offers her insight into the potential for stem cell use in cosmetic applications and the popular misconceptions and claims that may impede the future of this nascent therapy.