Eosinophilic esophagitis (EoE) is a chronic immune/antigen-mediated disorder characterized by eosinophilic infiltration of the esophageal wall leading to inflammation and progressive swelling of the esophagus. In this, the second of a two-part video, Gary W. Falk, MD, MS, of Penn Gastroenterology discusses the treatment, the guidelines and the future of therapy for EoE.