Director of the renowned Abramson Cancer Center, Chi Van Dang, MD, PhD, reviews the role of isocitrate dehydrogenase 1 (IDH1) mutations in the aberrant metabolism of cancers, and their contribution to the gliomas. Beginning with the metabolism of cell growth and proliferation, Dr. Dang analyzes the metabolic impact of cancer-associated IDH1 mutations in the gliomas and the effect of metabolic gene mutations on the metabolism of alpha-ketoglutarate and its dependent enzymes. Finally, Dr Dang discusses current efforts to target and block the activity of ADH1 to halt the progression of the gliomas.
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Published
December 23, 2015
Created by
BROADCASTMED