T­-Cell Immunotherapy for Brain Tumors: Using CAR Technology for Glioblastoma

Neurosurgeon Donald M. O’Rourke, MD, discusses recent developments in post­surgical immunological therapy for glioblastomas. Dr O’Rourke reviews brain cancer vaccine trials at Penn Medicine, focusing on the EGFRvIII peptide vaccine, offers a synopsis of the application at Penn of adoptive T cell therapy to the brain cancers and considers GBM­-surface antigens for CAR therapy in glioma.

 

 

Related Links

• Clinical Briefing: Neurosurgical Advances at Penn: Awake Craniotomy for Resection of Oligodendroglioma
• Penn Medicine Study Describes Development of Personalized Cellular Therapy for Brain Cancer
• Dr. O’Rourke’s Profile