In this revelatory and engaging presentation from 2014, Robert Vonderheide, MD, Phil, the Hanna Wise Professor in Cancer Research at Penn Medicine, discusses the immediate future for melanoma therapy. A leading researcher in cancer immunotherapy, Dr. Vonderheide reviews the spectrum of new and developing therapies for melanoma, including targeted CAR-modified T cell therapy, the reappearance of vaccine therapy, and combination treatments, including hypofractionated radiotherapy and immunotherapy.