Mary Ellen Martin, MD, discusses allogeneic stem cell transplantation for the myeloid and lymphoid disorders with reference to clinical presentations at ASH 2016. After a brief review of donor selection, conditioning, graft sourcing and standard GVHD prophylaxis, Dr Martin explores bridges to transplant, post-transplant relapse rescue and maintenance therapies, newer treatments for GVHD, treatment and prophylaxis of hepatic veno-occlusive disease and expanding the age limits for patients seeking transplant.